Audio Resource #2: Antibacterial Fatty Acids

Fatty acids and their derivatives are emerging as powerful natural agents against bacteria and fungi, including drug-resistant strains. Researchers have uncovered how these compounds disrupt microbial life through multiple mechanisms—damaging cell membranes, interfering with DNA replication, and even blocking communication between microbes. Some forms, like oxidized fatty acids (oxylipins), also show promise in controlling fungal toxins, with potential applications in medicine and food preservation.

Listen to this audio clip for an overview of how fatty acids are being explored as the next generation of antimicrobial solutions.

Sources:

1. Casillas-Vargas, G., Ocasio-Malavé, C., Medina, S., Morales-Guzmán, C., García del Valle, R., Carballeira, N. M., & Sanabria-Ríos, D. J. (2021). Antibacterial fatty acids: An update of possible mechanisms of action and implications in the development of the next-generation of antibacterial agents. Progress in Lipid Research, 82, 101093. Link​
2. Kabara, J. J., Swieczkowski, D. M., Conley, A. J., & Truant, J. P. (1972). Fatty acids and derivatives as antimicrobial agents. Antimicrobial Agents and Chemotherapy, 2(1), 23–28. Link
3. Churchward, C. P., Alany, R. G., & Snyder, L. A. S. (2018). Alternative antimicrobials: The properties of fatty acids and monoglycerides. Critical Reviews in Microbiology, 44(5), 561–570. Link‍
4. Guimarães, A., & Venâncio, A. (2022). The potential of fatty acids and their derivatives as antifungal agents: A review. Toxins (Basel), 14(3), 188. Link

Note: This audio clip was generated using AI to provide a clear and engaging overview of this topic. We value your feedback—let us know what you think.